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KMID : 1161420100130030650
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Journal of Medicinal Food
2010 Volume.13 No. 3 p.650 ~ p.656
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The Lipid-Lowering Effects of 4 Weeks of Daily Soymilk or Dairy Milk Ingestion in a Postmenopausal Female Population
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Beavers Kristen M.
Serra Monica C.
Beavers Daniel P.
Hudson Geoffrey M.
Willoughby Darryn S.
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Abstract
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Alterations in plasma cholesterol concentrations, especially increases in low-density lipoprotein (LDL), are well-known risk factors in the development of atherosclerosis. Numerous studies have examined the lipid-lowering effects of functional soy-containing foods, but few have specifically examined soymilk, with equivocal findings reported. In September 2008, a single-blind, randomized, controlled trial was conducted on 32 postmenopausal women at Baylor University, Waco, TX, USA. After a 2-week run-in period, subjects were randomly assigned to consume three servings of vanilla soy (n?=?16) or reduced-fat dairy (n?=?16) milk per day for 4 weeks. Plasma lipid profiles were obtained pre- and post-supplementation. Plasma high-density lipoprotein, LDL, and triglycerides were not significantly different between groups post-intervention (P?=?.45) or from baseline (P?=?.83). Separate analysis of plasma total cholesterol levels yielded similar results (P?=?.19 and P?=?.92, respectively). Furthermore, subanalyses controlling for dyslipidemia (n?=?23) and lipid-lowering medication usage (n?=?28) did not significantly alter results. Despite good dietary compliance, our study failed to show a significant hypocholesterolemic effect of soymilk consumption in this postmenopausal female population. Potential reasons for this nonsignificant finding are discussed, and future research directions are presented.
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KEYWORD
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cardiovascular disease, cholesterol, isoflavones, lipid lowering, soy
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